Drug-Free IVF Therapy

Drug-Free IVF Therapy

Memorial Hospital IVF Middle Gynecology and Obstetrics Specialist Op. Dr. Güvenç Karlıkaya gave details about IVM (In Vitro Maturation) and Pure Cycle, also called drug-free IVF software.

IVM is an in vitro fertilization technique utilized in ladies who’re extraordinarily delicate to hormone medicine and continues to be utilized in a number of facilities world wide.


IVM (In Vitro Maturation), to begin with hypersensitivity to hormone medicine It has emerged with the goal of creating IVF with out medicine in ladies with Polycystic Ovary Syndrome. IVM relies on the appliance of hormone medicine that stimulate the ovaries for a short while or the immature eggs collected with out utilizing any medicine are matured and fertilized within the exterior surroundings (within the laboratory) after which transferred into the uterus after they attain the suitable developmental stage.


A very powerful space of ​​use is in ladies with Polycystic Ovary Syndrome who reply to medicine excessively. On this case, IVM is aimed to stop the incidence of the syndrome referred to as OHSS (Ovarian Hyperstimulation Syndrome) in ladies with extraordinarily delicate ovaries. Other than this, it’s another technique for sufferers who’ve regular ovarian reserve however don’t need to use hormones.


Polycystic Ovary Syndrome is a vital ovulation drawback in ladies. This drawback could be seen in a single out of each 5 ladies within the society.

Two ovaries within the feminine physique develop 1 mature egg appropriate for fertilization in a single menstrual interval. This egg completes its growth and maturation in a fluid-filled sac referred to as “Follicle”. In Polycystic Ovary Syndrome; many eggs attempt to mature on the similar time, however fail to take action. In any case, there are numerous eggs, however none of them can develop and grow to be fertile. Within the ultrasound examination, the ovaries are seen as cysts, in different phrases, many sacs containing undeveloped eggs.


OHSS (Ovarian Hyperstimulation Syndrome – Ovarian Hyperstimulation Syndrome) happens in ladies who obtain follicle-stimulating hormone (FSH) remedy for egg growth. If a lot of eggs are developed throughout therapy, some uncomfortable side effects could happen inside two weeks of stimulation resulting from elevated ovarian dimension and excessive hormone ranges from these overexcited ovaries. Unwanted side effects:

• nausea, vomiting and diarrhea,
Ache that develops within the stomach resulting from enlarged ovaries,
Shortness of breath resulting from fluid accumulation within the lungs,
• Clot formation within the vessels resulting from elevated blood coagulation,
Distinct variations in physique fluid and electrolyte steadiness,
• Dehydration (dehydration of the physique).

In instances with extreme OHSS, the affected person needs to be hospitalized for statement and mattress relaxation.


Particularly ladies with Polycystic Ovary Syndrome are extraordinarily delicate to the results of medicine that stimulate the ovaries, and resulting from hormone medicine, they’ve the danger of creating Ovarian Hyperstimulation Syndrome, which is talked about above, whose uncomfortable side effects are fairly disturbing and typically even requires hospital therapy. The danger of OHSS is eradicated when in vitro fertilization is initiated with out stimulating the ovaries with medicine.
One other essential situation apart from this; For the reason that quantity of medicine used within the IVM process is far lower than the classical IVM technique, the therapy price is considerably diminished.


The characteristic that makes the IVM technique superior to medicated IVF therapy is the shortage of medicine. Alternatively, being pregnant charges with IVM technique are decrease than the medicated IVM. That is the primary purpose why IVM isn’t widespread regardless of its benefits. Success charges usually are not on the desired degree. It’s inevitable that this method will grow to be widespread with the introduction of recent and extra superior IVM tradition media.


In IVF therapy, in ladies who don’t need to use hormones, it’s the technique of taking the naturally rising and maturing egg simply earlier than the cracking stage and inseminating it exterior of the physique by in vitro fertilization. The one egg obtained right here could be developed and embryo could be obtained and being pregnant could be achieved by switch.
Nonetheless, the biggest group for which ‘pure cycle IVF therapy’ is advisable consists of sufferers who don’t reply to the classical IVF technique.
Supply: Memorial Hospital web site

Drug-Free IVF Therapy What is IVF treatment?

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